Cellcept(mycophenolate mofetil)
CellCept, Myclausen, Mycophenolate Mofetil, Myfenax, Myhibbin (mycophenolate mofetil) is a small molecule pharmaceutical. Mycophenolate mofetil was first approved as Cellcept on 1995-05-03. It is used to treat graft vs host disease and psoriasis in the USA. It has been approved in Europe to treat graft rejection. The pharmaceutical is active against inosine-5'-monophosphate dehydrogenase 2 and inosine-5'-monophosphate dehydrogenase 1.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Cellcept, Mycophenolate mofetil, Myhibbin (discontinued: Mycophenolate mofetil)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Mycophenolate mofetil
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| cellcept | New Drug Application | 2024-02-21 |
| mycophenolate mofetil | ANDA | 2024-11-06 |
| myhibbin | New Drug Application | 2024-05-07 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| psoriasis | EFO_0000676 | D011565 | L40 |
| graft vs host disease | — | D006086 | D89.81 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J7517 | Mycophenolate mofetil, oral, 250 mg |
Clinical
Clinical Trials
1294 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Kidney transplantation | D016030 | — | — | 20 | 52 | 55 | 122 | 28 | 263 |
| Leukemia | D007938 | — | C95 | 58 | 157 | 15 | 2 | 22 | 227 |
| Syndrome | D013577 | — | — | 30 | 83 | 7 | 3 | 11 | 120 |
| Graft vs host disease | D006086 | — | D89.81 | 16 | 38 | 13 | 6 | 7 | 70 |
| Recurrence | D012008 | — | — | 19 | 41 | 5 | 2 | 3 | 61 |
| Nephritis | D009393 | — | N05 | 1 | 19 | 18 | 9 | 12 | 58 |
| Lupus nephritis | D008181 | EFO_0005761 | — | 1 | 19 | 18 | 9 | 11 | 57 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 9 | 11 | 9 | 17 | 7 | 48 |
| Liver transplantation | D016031 | EFO_0010682 | — | 2 | 14 | 11 | 17 | 6 | 48 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 4 | 6 | 12 | 14 | 10 | 43 |
Show 119 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | 45 | 120 | 7 | — | 17 | 170 |
| Lymphoma | D008223 | — | C85.9 | 32 | 111 | 6 | — | 16 | 150 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 30 | 89 | 12 | — | 10 | 128 |
| Myeloid leukemia | D007951 | — | C92 | 28 | 86 | 11 | — | 9 | 122 |
| Preleukemia | D011289 | — | — | 32 | 80 | 3 | — | 12 | 114 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 23 | 69 | 7 | — | 9 | 99 |
| Multiple myeloma | D009101 | — | C90.0 | 24 | 68 | 4 | — | 13 | 98 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 17 | 65 | 6 | — | 9 | 88 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 14 | 63 | 7 | — | 6 | 82 |
| Hematologic neoplasms | D019337 | — | — | 24 | 57 | 4 | — | 6 | 76 |
Show 73 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelomonocytic leukemia juvenile | D054429 | — | C93.3 | 16 | 30 | — | — | 2 | 41 |
| Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 15 | 25 | — | — | 2 | 35 |
| Plasmacytoma | D010954 | — | C90.3 | 7 | 23 | — | — | 5 | 32 |
| B-cell lymphoma | D016393 | — | — | 4 | 23 | — | — | 5 | 29 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 3 | 22 | — | — | 5 | 28 |
| Aplastic anemia | D000741 | HP_0001915 | D61.9 | 4 | 21 | — | — | 3 | 26 |
| T-cell lymphoma | D016399 | — | — | 5 | 20 | — | — | 4 | 26 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 8 | 10 | — | — | 2 | 17 |
| Myeloid leukemia accelerated phase | D015465 | — | — | 5 | 13 | — | — | 2 | 17 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | 3 | 13 | — | — | 3 | 17 |
Show 162 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | 3 | — | — | — | 3 | 6 |
| Islets of langerhans transplantation | D016381 | — | — | 1 | — | — | — | 2 | 3 |
| Glioblastoma | D005909 | EFO_0000515 | — | 2 | — | — | — | — | 2 |
| Astrocytoma | D001254 | EFO_0000271 | — | 2 | — | — | — | — | 2 |
| Chronic granulomatous disease | D006105 | EFO_0000338 | D71 | 1 | — | — | — | 1 | 2 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
| Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
| Germ cell and embryonal neoplasms | D009373 | — | — | 1 | — | — | — | — | 1 |
| Medulloblastoma | D008527 | — | — | 1 | — | — | — | — | 1 |
| Rhabdoid tumor | D018335 | — | — | 1 | — | — | — | — | 1 |
Show 11 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bone diseases | D001847 | — | M89.9 | — | — | — | — | 2 | 2 |
| Proteinuria | D011507 | HP_0000093 | R80 | — | — | — | — | 2 | 2 |
| Infertility | D007246 | HP_0000789 | — | — | — | — | — | 2 | 2 |
| Uveomeningoencephalitic syndrome | D014607 | Orphanet_3437 | H20.82 | — | — | — | — | 2 | 2 |
| Heart disease risk factors | D000082742 | — | — | — | — | — | — | 1 | 1 |
| Antibody formation | D000917 | — | — | — | — | — | — | 1 | 1 |
| Choroidal neovascularization | D020256 | — | — | — | — | — | — | 1 | 1 |
| Pathologic neovascularization | D009389 | — | — | — | — | — | — | 1 | 1 |
| Scleritis | D015423 | HP_0100534 | H15.0 | — | — | — | — | 1 | 1 |
| Lysosomal storage diseases | D016464 | — | — | — | — | — | — | 1 | 1 |
Show 22 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Mycophenolate mofetil |
| INN | — |
| Description | Mycophenolic acid is a member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases. It has a role as an antineoplastic agent, an antimicrobial agent, an EC 1.1.1.205 (IMP dehydrogenase) inhibitor, an immunosuppressive agent, a mycotoxin, a Penicillium metabolite, an environmental contaminant, a xenobiotic and an anticoronaviral agent. It is a gamma-lactone, a member of phenols, a monocarboxylic acid and a member of 2-benzofurans. It is functionally related to a hex-4-enoic acid. It is a conjugate acid of a mycophenolate. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)OCCN1CCOCC1)C(=O)OC2 |
Identifiers
| PDB | — |
| CAS-ID | 24280-93-1 |
| RxCUI | 7145 |
| ChEMBL ID | CHEMBL1456 |
| ChEBI ID | 8764 |
| PubChem CID | 446541 |
| DrugBank | DB00688 |
| UNII ID | — |
Target
Agency Approved
IMPDH1
IMPDH1
Organism
Homo sapiens
Gene name
IMPDH1
Gene synonyms
IMPD1
NCBI Gene ID
Protein name
inosine-5'-monophosphate dehydrogenase 1
Protein synonyms
IMP (inosine 5'-monophosphate) dehydrogenase 1, IMP (inosine monophosphate) dehydrogenase 1, IMPD 1, IMPDH 1, IMPDH-I
Uniprot ID
Mouse ortholog
Impdh1 (23917)
inosine-5'-monophosphate dehydrogenase 1 (P50096)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Cellcept – Roche
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Estimated US medical usage
Mycophenolate mofetil
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 39,978 documents
View more details
Safety
Black-box Warning
Black-box warning for: Cellcept, Mycophenolate mofetil, Myhibbin
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
85,327 adverse events reported
View more details
© 2020-2024 Collaborative Drug Discovery Inc. (CDD) | Terms of Use